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Communication | Regular issue | Vol 27, No. 12, 1988, pp.2791-2794
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4750
A New Synthesis of 5-Aza[2.2.3]cyclazines by [8+2]Cycloaddition of 3-Imino-3H-pyrrolizines with Dimehtyl Acetylenedicarboxylete

Yoshinori Tominaga,* Yoshiki Matsuoka, and Akira Hosomi*

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan

Abstract

Reaction of 3-imino-3H-pyrrolizines, generated in situ, with dimethyl acetylenedicarboxylate (DMAD) in the presence of palladium on charcoal in toluene gave 5-aza-[2.2.3]cyclazine derivatives in good yields.