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Communication | Regular issue | Vol 27, No. 9, 1988, pp.2087-2090
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4644
1,3-Oxazolindid-5-ones, not 1,3-Diazetidinones, are Formed in the Reaction of Tryptophan with Alkyl Isocyanates in the Presence of Acetone

Alf Claesson*

*Research and Development Laboratories, Astra Alab, SE-151 85 Södertälja, Sweden


A recent paper in This Journal by Braña et al. (Heterocycles 1987, 26, 95) reports isolation of 2-[(3-alkyl-4,4-dimethyl-2-oxo)-1,3-diazetidinyl]-3-(3-indolylpropionic acids from reactions of tryptophan with alkyl isocyanates in acetone. It appears most likely that these products are instead 1,3-oxazolidin-5-ones.