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Communication | Regular issue | Vol 27, No. 9, 1988, pp.2071-2075
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4628
Synthesis of Pyrrole, Pyrrolidone, Pyrrolo[3,4-c]pyrazole, Pyrrolo[3,2-b]pyridine and Pyrrolo[3,2-b]pyrrole Derivatives

Afaf A. A. Elbannany and Laila I. Ibrahim

*Department of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt


A facile and one step route for the synthesis of substituted pyrroie derivatives 5a-g from reaction of ethyl arylidenecyanoacetate (1) with glycine (2) was reported. Also the pyrrolidone derivative ,12 was formed upon reaction of benzylidenemalononitrile (7) with 2 The synthesized 5 has been used as a precursor in the syntheses of pyrrolo[3,4-c]pyrazole 13, pyrrolo[3,2-b]pyridine 15 or its tautomer 16 and pyrrolo[3,2-b]pyrrole derivatives 18.