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■ Antimicrobial Agents from Higher Plants. The Isolation and Structural Characterization of Two Additional Pterocarpan Antimicrobial Agents from Nigerian Erythrina mildbraedii

Lester A. Mitscher,* Simon K. Okwute, Sitaraghav R. Gollapudi, and Ali Keshavarz-Shokri

*Department of Medicinal Chemistry, Kansas University, Lawrence, Kansas 66045, U.S.A.

Abstract

Examination of bioactive mother-liquors from previous large scale experiments on the antimicrobial agents from the Nigerian medicinal plant, Erythrira mildbraedii, led to the isolation and structural characterization of two new pterocarpans, erybraedin D and E. Erybraedin D was initially isolated as its apparently artifactual hemiethyl phthalate ester. Both new pterocarpans possess marginal antimicrobial potency in vitro.