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Paper | Regular issue | Vol 27, No. 9, 1988, pp.2177-2183
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4613
An Efficient Synthesis of 5-Aryl(or Alkyl)amino-4-ethoxycarbonyl-2-methylthio-1,3-thiazoles from Dimethyl N-(Ethoxycarbonylmethyl)iminodithiocarbonate and Isothiocyanates

Carlos Alvarez-Ibarra,* Matilde Gil, Paloma Ortiz, and Maria L. Quiroga

*Departamento de Química Orgánica, Facultad de Química, Universidad Complutense de Madridas, Ciudad Universitaria, E-28040 Madrid, Spain


An efficient synthesis of perfunctlonalyzed 1,3-thiazoles 2a-2b with good Yields has been carried out by a cyclocondensation reaction between the α-metallated dimethyl N-(ethoxycarbonylmethyl)iminodithiocarbonate and aryl or alkylisothiocyanates.