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Paper | Regular issue | Vol 27, No. 8, 1988, pp.1881-1885
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4553
Synthesis of New Uraciles Having N-Amino-β-,γ- and δ-lactams

Tadashi Okawara, Toshifumi Shono, Tetsuo Yamasaki, and Mitsuru Fiurukawa*

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan


The reaction of 1,3-dimethyl-6-methylhydrazinouracil 1 with various haloacyl halides 2 afforded N-haloacylhydrazinouraciles 3, which were converted into the corresponding lactams 4 by treatment with KOH in the presence of BTEAC.