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Paper | Regular issue | Vol 27, No. 8, 1988, pp.1867-1871
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4530
Synthesis of 2-Alkylpyrimidines via 2-Alkyl-1,4,5,6-tetrahydropyrimidines

Richard Garth Pews*

*Organic Specialties Laboratory, Central Research, The Dow Chemical Company, 1776 Building, Midland, Michigan 48674, U.S.A.


The condensation of 1,3-diaminopropane with alkanoic acids gives 2-alkyl-1,4,5,6-tetrahydropyrimidines. Dehydrogenation of the tetrahydropyrimidine derivatives over a palladium catalyst produces the 2-alkylpyrimidines in high yields.