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Paper | Regular issue | Vol 27, No. 6, 1988, pp.1421-1429
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4509
A Facile Preparation of D-Penicillamine. Reaction of Benzylpenilloic Acid and Arylamines

Toshihisa Ogawa,* Kazuyuki Tomisawa, and Kaoru Sota

*Research Center, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-Cho, Saitama-city, Saitama 330-8530, Japan

Abstract

The preparation of D-penicillamine (3) was achieved by the reaction of benzylpenllloic acid (1) with arylamines (2, 7, 13, 15) through ring fission of thiazolidine. The structures of the by-products formed in these reactions were determined.