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■ Facile Synthesis of Pyrazole[3,4-b]-pyridines

Abdulla Babaqi, Ali El-Shekeil,* Mohammed Hassan, and Sayed Shiba

*Chemistry Department, Faculty of Science, Sana‘s University, Sana‘s, Yemen

Abstract

The base-catalyzed Michael addition of cyclohexanone, 1,3-diphenyl-2-pyrazolin-5-one, ethyl acetoacetate, and diethyl malonate on 1-aryl-3-(5-chloro-1,3-diphenyl-1H-4-pyrazolyl)-prop-2-en-1-ones (2) in the presence of ammonium acetate at 130°C gave the corresponding pyrazolo [3,4-b] pyridine derivatives (3-6). Structures were confirmed by microanalysis, ir, ¹H-nmr, and 13C-nmr.