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Paper | Regular issue | Vol 27, No. 6, 1988, pp.1401-1410
Published online, 1st January, 1970
DOI: 10.3987/COM-88-4490
Studies in the Chemical Constituents of the Seeds of Pegnum harmala: Isolation and Structure Elucidation of Two β-Carboline Lactams - Harmalanine and Harmalacidine

Salimuzzaman Siddiqui,* Obaid Yusuf Khan, Shaheen Faizi, and Bina Shaheen Siddiqui

*H. E. J. Postgraduate Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

Abstract

Two β-carboline lactams harmalanine and harmalacidine have been isolated from the seeds of Peganum harmala and their structures were elucidated as I and II respectively through chemical and spectroscopic studies. In the case of I, which is the simplest tetracyclic β-carboline lactam from any source, detailed nmr (1H and 13C) investigations including noe difference, 2D nmr (cosy-45, noesy, J-resolved) double resonance experiments and 1H-13C-hetero-COSY measurements have been used.