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Paper | Regular issue | Vol 27, No. 7, 1988, pp.1623-1628
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4475
Optimization of the Synthesis of N(1)-(2-Aminoethyl)-NAD(P)

Andreas F. Bückmann*

*Research Group Microbial Ecology, GBF - National Research Center for Biotechnology, Mascheroder Weg 1, D-38124 Braunschweig, Germany

Abstract

The alkylation of NAD(P) to N(1)-(2-aminoethyl)-NAD(P) with ethyleneimine in aqueous solution was optimized. First the pH-dependency of the alkylation of the N (1)-position of the adenine nucleus of NAD was studied in the pH range 2-5.5 at 20°C. followed by adjusting the temperature and the concentration of ethyleneimine to achieve acceptable reaction times. The results were directly applicable with respect to the synthesis of N(1)-(2-aminoethyl)-NADP.