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Communication | Regular issue | Vol 27, No. 4, 1988, pp.885-888
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4471
Synthesis of Hypoxanthine 7-Oxide, a New N-Oxide at the 6-Oxopurine Level

Kazuo Ogawa, Tohru Saito, Fujio Nohara, Masahiro Nishii, Taisuke Itaya, and Tozo Fujii*

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

Hypoxanthine 7-oxide (IV) has been synthesized for the first time from 6-chloro-5-nitro-4(3H)-pyrimidinone (I) through the intemediates II and V; catalytic hydrogenolysis, methylation followed by catalytic hydrogenolysis, and isomerization under acidic conditions of IV supported the correctness of the assigned structure.