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Communication | Regular issue | Vol 27, No. 5, 1988, pp.1119-1122
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4463
Novel Synthesis of Quinolone-3-sulfonic Acid Derivatives

Choung Un Kim* and Bing-Yu Luh

*Pharmaceutical Reearch and Development, Bristol-Myers Company, P. O. Box 5100, Wallingford, CT 06492-5100, U.S.A.


The synthesis of 1-ethyl-6-fluoro-7-(1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-sulfonic acid is described. The use of a 2-bromophenyl sulfonate as a protected sulfonic acid is readily hydrolyzed under basic conditions is described.