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Communication | Regular issue | Vol 27, No. 4, 1988, pp.871-874
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4446
A Total Synthesis of (±)-Corydalic Acid Methyl Ester

Robin D. Clark and Jahangir

*Institute of Organic Chemistry, Syntex Research, Palo Alto, California 94304, U.S.A.


A highly stereoselective synthesis of (±)-corydalic acid methyl ester (1) is reported. The key step involved cyclocondensation of the lithio derivative of amide 6 with imine 7 which afforded the trans-3-aryl-4-methyl-3,4-dihydro-1(2H)-isoquinolone 5 which was further elaborated to 1.