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Paper | Regular issue | Vol 27, No. 3, 1988, pp.751-768
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4416
Hofmann Elimination with Diazomethane on Quaternary Benzyltetrahydroisoquinoline Related Alkaloids

Sheng-Teh Lu* and Ian-Lih Tsai

*School of Pharmacy, Kaohsiung Medical College, 100 Shih Chuen 1st Rd., Kaohsiung 80708, Taiwan, R.O.C.


The investigation have been made to the reaction of a large excess of diazomethane on the quaternary henzyltetrahydroisoquinoline related alkaloids, aporphines, benzyltetrahydroisoquinolines, pavines and protopine. From the structural elucidation of the reaction products, it has been found that the first and second Hofmann elimination proceeded.