Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 27, No. 4, 1988, pp.897-901
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4415
C-(11)-Epi-deoxyarteether: Formation and Structure

Lourdes Dominguez Gerpe, Herman J. C. Yeh, Qian-Sheng Yu, Arnold Brossi, and Judith L. Flippen-Anderson*

*Section of Medicinal Chemistry, Laboratory of Bioorganic Chrmistry, NIDDK, National Institute of Health, Bethesda, MD 20892, U.S.A.

Abstract

Acid catalyzed etherification of deoxydihydroqinghaosu (1) with ethanol saturated with hydrogen chloride afforded 11-epi-deoxyarteether (5). Compound 5 also was obtained from deoxyethern 2 and 3 and the vinylic ether 4 under the same reaction conditions. The configuration at C-l1 and C-12 of 5, strongly supported by 1H-nmr data, has been confirmed by X-ray analysis.