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■ Practical Synthesis of Unnatural (+)-Physostigmine and Carbamate Analogues

Qian-Sheng Yu and Arnold Brossi

*Medical Chemistry Section, Laboratory of Chemistry, NIDDK, National Institute of Health, Bethesda, MD 20892, U.S.A.

Abstract

Details of a synthesis of unnatural (+)-physostigmine (5) prepared from urea 1 via (+)- eseroline (4) are given. Preparation of (+)-octylcarbamate 6, (+)-benzylcarbamate 7, (+)-phenylcarbamate 8 and (+)-N-methylphysostigmine (9) from (+)-eseroline (4) is also described.