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■ Synthesis of Vinca Alkaloids and Related Compounds XXXV¹. Preparation of 1-Ethyl-1-hydroxyethyl-octahydroindolo[2,3-a]quinolizine Derivatives and Reactions of Their Mesylates with Cyanide Ion

György Kalaus, Numan Malkieh, Mária Kajtár-Peredy, János Brlik, Lajos Szabó, and Csaba Szántay*

*Institute of Organic Chemistry, Technical University, 1521 Budapest, Hungary

Abstract

Starting from (±)-eburnamonine (1a) and (±)-3-epieburnamonine (1b), compounds 5 and 11 were prepared. The reaction of the mesylate of 5 or 11 with NaCN in DMF led to a mixture of 16 and 17. The structures of the new compounds were elucidated.