Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 27, No. 2, 1988, pp.315-318
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4354
Novel Cyclization of Ethyl 2-Bromopyruvate with Dialkylthioamides of N-Protected Amino Acids: One Pot Synthesis of 1,2,3,5-Tetrasubstituted Pyrroles

Tarek S. Mansour* and Gilles Sauvé

*Biochemical Products Division, Institut Armand-Frappier, Université du Québec, 531 Boulevard de Prairies, Laval, Québec, H7V 1B7, Canada

Abstract

Reaction of ethyl 2-bromopyruvate (1) with various N-t-Boc, N-ethoxycarbonyl or N-acetyl phenylalanine or methionine dialkylthioamides under sulfur extrusion conditions gave 1,2,3,5-tetrasubstituted pyrroles in good yields.