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Communication | Regular issue | Vol 27, No. 2, 1988, pp.315-318
Published online, 1st January, 1970
DOI: 10.3987/COM-87-4354
Novel Cyclization of Ethyl 2-Bromopyruvate with Dialkylthioamides of N-Protected Amino Acids: One Pot Synthesis of 1,2,3,5-Tetrasubstituted Pyrroles

Tarek S. Mansour* and Gilles Sauvé

*Biochemical Products Division, Institut Armand-Frappier, Université du Québec, 531 Boulevard de Prairies, Laval, Québec, H7V 1B7, Canada


Reaction of ethyl 2-bromopyruvate (1) with various N-t-Boc, N-ethoxycarbonyl or N-acetyl phenylalanine or methionine dialkylthioamides under sulfur extrusion conditions gave 1,2,3,5-tetrasubstituted pyrroles in good yields.