HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Mannich Reaction of 5-Hydroxy-β-carboline. Application to the Synthesis of Novel Oxazinopyrimidocarboline Derivatives

Samar Issa, Nadia Walchshofer, Issam Kassab, Jacques Gentili, Aziz Geahchan, and Zouhair Bouaziz*

*University of Lyon, Lyon, F-69003, France

Abstract

5-Hydroxy-β-carboline 4 was synthesized and submitted to the Mannich reaction towards formaldehyde and some primary amines. It undergoes an original reaction of bis-aminomethylation-cyclisation giving the oxazinopyrimidocarboline derivatives 5a-d. The structure of these compounds was confirmed by their high-resolution mass, IR, ¹H NMR and ¹³C NMR spectral data.