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Paper | Regular issue | Vol 75, No. 10, 2008, pp.2493-2505
Published online, 29th May, 2008
DOI: 10.3987/COM-08-11415
Reactions of Alkylation of Biologically Interesting Triazolo[4,5-g]quinolines and Triazolo[4,5-g]quinoline-1-oxides with Electrophilic Reagents

Antonio Carta,* Angela Sias, Sandra Piras, and Giuseppe Paglietti

*Department of Medicinal and Toxicological Chemistry, University of Sassari, Via Muroni 23, 07100 Sassari, Italy

Abstract

With the aim to improve the biological activities discovered for compounds containing the triazolo[4,5-g]quinoline nucleus, we describe the chemical behaviour of 4-chlorotriazolo[4,5-g]quinolines (1a,b) and some its triazolo-N1-oxide derivatives (1c-e and II) with electrophilic reagents in order to optimize the synthetic pathways for obtaining both mixtures of N1,2,3-alkyl isomers and selectively N1-O-alkyl derivatives.