Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 75, No. 10, 2008, pp.2421-2428
Published online, 29th May, 2008
DOI: 10.3987/COM-08-11406
Guanidine-Annelated Heterocycles XVI. A Practical Synthesis of 7-Chloro-4-phenylamino[1,2,4]triazoloquinazolin-5(4H)-ones

Wen-Chuan Hsu,* Pei-Wen Shan, Yi-Chen Huang, Kang-Chien Liu, and Tsu-Chung Chang*

*Department of Biochemistry, bPharmaceutical Research Institute, National Defense Medical Center, Taipei, Taiwan, R.O.C.


The triazolo[2,3-a]quinazolin-5(4H)-ones 9a-c can be prepared via Dimroth rearrangement by treatment of 5 with representative carboxylic acid orthoesters 6a-c each heating at 40 °C more elevated temperature than the preparation of their analogous triazolo[4,3-a] isomers 7a-c.