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Paper | Regular issue | Vol 75, No. 10, 2008, pp.2421-2428
Published online, 29th May, 2008
DOI: 10.3987/COM-08-11406
Guanidine-Annelated Heterocycles XVI. A Practical Synthesis of 7-Chloro-4-phenylamino[1,2,4]triazoloquinazolin-5(4H)-ones

Wen-Chuan Hsu,* Pei-Wen Shan, Yi-Chen Huang, Kang-Chien Liu, and Tsu-Chung Chang*

*Department of Biochemistry, bPharmaceutical Research Institute, National Defense Medical Center, Taipei, Taiwan, R.O.C.

Abstract

The triazolo[2,3-a]quinazolin-5(4H)-ones 9a-c can be prepared via Dimroth rearrangement by treatment of 5 with representative carboxylic acid orthoesters 6a-c each heating at 40 °C more elevated temperature than the preparation of their analogous triazolo[4,3-a] isomers 7a-c.