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Note | Regular issue | Vol 75, No. 10, 2008, pp.2523-2533
Published online, 12th June, 2008
DOI: 10.3987/COM-08-11405
Green Approach for the Efficient Synthesis of Quinolines Promoted by Citric Acid

Ramu Enugala, Sreelatha Nuvvula, Vijay Kotra, Ravi Varala, and Srinivas R. Adapa*

*I&PC Division, Indian Institute of Chemical Technology, Hyderabad, India-500 007


Citric acid promoted Friedlander synthesis of a mini-library of poly substituted quinolines (30 examples) at 100 °C under solvent-free conditions was achieved in moderate to excellent yields (54-99%). The method is simple, cost-effective and environmentally benign.