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Note | Regular issue | Vol 75, No. 9, 2008, pp.2293-2299
Published online, 24th April, 2008
DOI: 10.3987/COM-08-11391
A Clean Synthesis of 3,3-Bis(5-Amino-1H-pyrazol-4-yl)-indolin-2-one Derivatives

Somayeh Ahadi, Ghazaleh Imani Shakibaei, Peiman Mirzaei, and Ayoob Bazgir*

*Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran 1983963113, Iran


A clean and efficient method has been reported for the condensation of 1,3-diphenyl-1H-pyrazol-5-amine with isatines in aqueous media to afford the corresponding 3,3-bis(5-amino-1H-pyrazol-4-yl)indolin-2-one derivatives in good yields.