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Paper | Regular issue | Vol 75, No. 8, 2008, pp.1983-1995
Published online, 17th April, 2008
DOI: 10.3987/COM-08-11385
Bioactive Constituents from Chinese Natural Medicines. XXXI. Hepatoprotective Principles from Sinocrassula indica: Structures of Sinocrassosides A8, A9, A10, A11, and A12

Kiyofumi Ninomiya, Toshio Morikawa, Haihui Xie, Hisashi Matsuda, and Masayuki Yoshikawa*

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan


The methanolic extract from the whole plant of Sinocrassula indica (Crassulaceae) was found to show hepatoprotective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the methanolic extract, five new acylated flavonol glycosides, sinocrassosides A8 (1), A9 (2), A10 (3), A11 (4), and A12 (5), were isolated together with 25 compounds. The structures of 1-5 were elucidated on the basis of chemical and physicochemical evidence. Among the isolated compounds, sinocrassosides A1 (6), A2 (7), and B2 (14) were found to show potent hepatoprotective effect.