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Note | Regular issue | Vol 75, No. 9, 2008, pp.2275-2282
Published online, 28th April, 2008
DOI: 10.3987/COM-08-11364
The Regioselective Synthesis of 2H-Pyrido[2,3-b]pyrrolo[2,3-e]pyrazin-2-one

Krzysztof Jamrozy, Katarzyna Szymoniak, and Katarzyna Ostrowska*

*Department of Organic Chemistry, Jagiellonian University, R. Ingardena 3, PL-30060 Kraków, Poland


The regioselective reaction of 1-aryl-4-(phenylhydroxymethylidene)- pyrrolidine-2,3,5-triones 1 with 2,3-diaminopyridine in boiling glacial AcOH in the presence of TsOH led to the formation of new 2H-pyrido[2,3-b]pyrrolo[2,3-e]pyrazin-2-ones. The structure of this fused heterocyclic system was confirmed by IR, 1D and 2D NMR experiments.