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Note | Regular issue | Vol 75, No. 7, 2008, pp.1773-1778
Published online, 29th February, 2008
DOI: 10.3987/COM-08-11354
A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines

Hua-pei Jian, Xing-yuan Wang, Zhi-shu Huang, Shi-liang Huang,* and Lian-quan Gu

*School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, P. R. China


A series of novel heteropolycyclic pyrazines and oxazoles were synthesized by the reaction of 2,3-dihydrobenzo[de]chromene-7,8-dione (compound 1) with amines in mild reaction conditions. The mechanisms for these reactions were discussed.