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Note | Regular issue | Vol 75, No. 7, 2008, pp.1765-1772
Published online, 4th March, 2008
DOI: 10.3987/COM-08-11347
A Facile Synthesis of Imidazo[1,5-b]pyridazines from 3-Formylchromones

Andrey S. Plaskon, Sergey V. Ryabukhin,* Dmitriy M. Volochnyuk, Alexander N. Shivanyuk, and Andrey A. Tolmachev

*Enamine Ltd. 23 A. Matrosova st., 01103 Kyiv, Ukraine


The recyclization of 3-formylchromones promoted by chlorotrimethylsilane with 1-amino-1H-imidazoles results in a set of imidazo[1,5-b]pyridazines is obtained in high preparative yields. It‘s found that the reaction is sensitive to the structure of NNC-binucleophiles.