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Note | Regular issue | Vol 75, No. 7, 2008, pp.1757-1764
Published online, 4th April, 2008
DOI: 10.3987/COM-08-11345
Thiophene Derivatives from the Aerial Part of Pluchea indica

Yun-Qi Qiu, Shu-Hua Qi, Si Zhang,* Xin-Peng Tian, Zhi-Hui Xiao, MIn-Yi Li, and Qing-Xin Li

*1Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, P. R. China

Abstract

Chemical investigation on the aerial part of Pluchea indica resulted in the isolation of two new thiophene derivatives, 2-(4-hydroxy-3- methoxybut- 1-yn-1-yl)-5-(penta-1,3-diyn-1-yl)thiophene (1) and 2-(4-O-β-glucopyranosyl- 3-hydroxybut-1-yn-1-yl)-5-(penta-1,3-diyn-1-yl)thiophene (2) along with three known thiophene derivatives 2-(3,4-dihydroxybut-1-yn-1-yl)-5-(penta-1,3-diyn-1-yl)thiophene (3), 2-(3-acetoxy-4-hydroxybut-1-yn-1-yl)-5-(penta-1,3-diyn-1-yl) thiophene (4) and 2-(prop-1-yn-1-yl)-5-(6-acetoxy-5-hydroxyhexa-1,3-diyn-1-yl) thiophene (5). The structures of 1 and 2 were determined on the bases of extensive spectroscopic analysis, including 1D and 2D NMR data. Antimicrobial activities of compounds 1-5 were tested.