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Paper | Regular issue | Vol 75, No. 8, 2008, pp.1913-1929
Published online, 1st April, 2008
DOI: 10.3987/COM-08-11326
Solvent-Free Microwave Synthesis of 3-(4-Benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New Hetero Bis-Ligands with Potential 5-HT1A Serotonergic Activity

Hernán Pessoa-Mahana,* Johann Kosche C., Nadia Ron H., Gonzalo Recabarren-Gajardo, Claudio Saitz B., Ramiro Araya-Maturana, and C. David Pessoa-Mahana

*Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Casilla 233, Santiago 1, Chile


A novel series of 2-benzothiophenealkylpiperazine derivatives 11(a-d) with potential affinity at 5-HT1A serotonine receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).