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Paper | Regular issue | Vol 75, No. 7, 2008, pp.1631-1638
Published online, 29th February, 2008
DOI: 10.3987/COM-08-11323
Synthesis of Pyrrolo[2,3-d]pyrimidine Analogues of the Potent Antitumor Agent N-{4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl}-L- glutamic Acid (TNP-351)

Gaojun Zhu, Zenglu Liu, Yun Xu, and Zhenmin Mao*

*School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, PR China

Abstract

Two three-atom-bridged analogues of TNP-351, N-(4-{[(2-amino- 4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)amino]methyl}- benzoyl)-L-glutamic acid (4) and N-(4-{[(2,4-diamino-7H-pyrrolo[2,3-d]- pyrimidin-5-ylmethyl)amino]methyl}benzoyl)-L-glutamic acid (5) were synthesized as anticancer agents, and their biological activities were evaluated.