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Paper | Special issue | Vol 73, No. 1, 2007, pp.341-348
Published online, 5th June, 2007
DOI: 10.3987/COM-07-S(U)7
Taxezopidines O and P, New Taxoids from Taxus cuspidata

Haruaki Ishiyama, Yuka Kakuguchi, Eri Arita, and Jun’ichi Kobayashi*

*Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

Abstract

Two new taxoids, taxezopidines O (1) and P (2), have been isolated from seeds of the Japanese yew Taxus cuspidata, and the structures and relative stereochemistry were elucidated on the basis of spectroscopic data. The absolute stereochemistry of a 3-N-methylamino-3-phenylpropanoyl group in 1 was determined by HPLC analysis for FDAA (1-fluoro-2,4-dinitrophenyl-5-L-alanine amide) derivative of hydrolysate of 1.