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Communication | Special issue | Vol 73, No. 1, 2007, pp.183-186
Published online, 25th July, 2007
DOI: 10.3987/COM-07-S(U)22
Synthesis of 3-O-Acylated Epicatechin Derivatives via Sequential One-Pot Multi-Step Reactions

Makoto Kitade, Hiroshi Tanaka, and Takashi Takahashi*

*Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan


An effective approach for the synthesis of epicatechin derivatives based on sequential one-pot multi-step reactions is described. Reductive etherification of the disulfanyl derivative was promoted with a catalytic amount of TfOH, providing the cis-substituted benzopyran derivative in a stereoselective manner.