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Communication | Special issue | Vol 73, No. 1, 2007, pp.177-182
Published online, 28th August, 2007
DOI: 10.3987/COM-07-S(U)17
New End-On Thiolactone Scaffold by an Isocyanide-Based Multicomponent Reaction

Barbara Beck, Stuti Srivastava, and Alexander Dömling*

*Departments of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, Pittsburgh, PA 12580, USA


The three component reaction of homocysteine, an oxocomponent and an isocyanide smoothly and stereoselectively yields N-substituted 2-(2-oxotetrahydrothiophen-3-ylamino)acetamides. In this communication we present our preliminary results on six compounds derived from this unprecedented reaction.