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Paper | Regular issue | Vol 75, No. 5, 2008, pp.1163-1189
Published online, 8th February, 2008
DOI: 10.3987/COM-07-11302
Synthesis and Biological Evaluations of New Pyrrolo[2,3-b]pyrimidine as SDI Analogs

Jérôme Guillard and Marie-Claude Viaud-Massuard*

*EA 3857 Laboratoire de Synthèse et Physicochimie, Organique et Thérapeutique, University of Tours, 31 Avenue de Monge, 37200 Tours, France

Abstract

The synthesis of new pyrrolo[2,3-d]pyrimidines variously substituted on the N-1 and C-2 atoms are described. Access to these compounds, which have modest activity compared with the first inhibitor SDI, involves, as the key step, the formation of a pyrrolopyrimidine skeleton from the 5-amino-2-(methoxymethyl)pyrimidine.