Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Special issue | Vol 76, No. 1, 2008, pp.267-273
Published online, 25th January, 2008
DOI: 10.3987/COM-07-11296
Cycloaddition of 2-Pyridones Having an Electron-Withdrawing Group

Masato Hoshino, Hisao Matsuzaki, and Reiko Fujita*

*Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan

Abstract

Cycloaddition of 1-methyl-2(1H)-pyridones bearing an electron-withdrawing group at 3-5 positions acting as the diene with N-phenylmaleimide was carried out under atmospheric and high pressure conditions to give the corres-ponding isoquinuclidines. Stereoselectivity of the cycloaddition of 1-methyl-2(1H)-pyridones was investigated using molecular orbital calculations.