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Paper | Regular issue | Vol 75, No. 4, 2008, pp.879-885
Published online, 11th January, 2008
DOI: 10.3987/COM-07-11285
Synthesis and Evaluation of Influenza Virus Sialidase Inhibitory Activity of Hinokiflavone-Sialic Acid Conjugates

Kazuhiko Miki, Takayuki Nagai, Takayuki Nakamura, Mitsuru Tuji, Kiyotaka Koyama, Kaoru Kinoshita, Kimio Furuhata, Haruki Yamada, and Kunio Takahashi*

*Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose-shi, Tokyo 204-8588, Japan

Abstract

The known biflavonoid, hinokiflavone (1) was isolated from the leaves of Metasequoia glyptostroboides Hu et Cheng and displayed influenza A and B virus sialidase inhibitory activity. The unnatural glycoconjugate, hinokiflavone-sialic acid (8) was synthesized and exhibited more potent inhibitory activity.