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Note | Regular issue | Vol 75, No. 4, 2008, pp.947-954
Published online, 11th January, 2008
DOI: 10.3987/COM-07-11273
Green Protocol for the Friedländer Synthesis: KAl(SO4)2·12H2O-SiO2 (Alum- SiO2), a Highly Efficient Catalyst in the Synthesis of Quinolines

Ali A. Mohammadi,* Javad Azizian, Armin Hadadzahmatkesh, and Mohammad R. Asghariganjeh

*Department of Chemistry, Faculty of Science, Shahid Beheshti University, P. O. Box 19395-4716, Tehran, Iran


In this letter, an efficient synthesis of an array of poly-substituted quinolines from 2-aminoaryl ketones and β-ketoester, β-diketones and α-methylene ketones using KAl(SO4)2·12H2O-SiO2 (Alum-SiO2) under solvent-free conditions is described. Compared with the classical Friedländer synthesis this new synthetic method has the advantage of excellent yields (90-98%), shorter reaction time, and reusability of the catalyst.