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Note | Regular issue | Vol 75, No. 4, 2008, pp.925-932
Published online, 18th December, 2007
DOI: 10.3987/COM-07-11264
Rapid Synthesis of New Azaheterocyclic Hydroxymalonate Derivatives Using TDAE Approach

Marc Montana, Maxime D. Crozet, Caroline Castera-Ducros, Thierry Terme, and Patrice Vanelle*

*Laboratory of Pharmaceutical Organic Chemistry, CNRS-UMR 6517, University of Méditerranée, Faculty of Pharmacy, 27 bd Jean Moulin, 13385 Marseille cedex 5, France

Abstract

A new series of azaheterocyclic hydroxymalonate derivatives was synthesized from reaction between chloromethyl azaheterocycles and diethyl oxomalonate using tetrakis(dimethylamino)ethylene (TDAE).