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Note | Regular issue | Vol 75, No. 4, 2008, pp.919-924
Published online, 18th December, 2007
DOI: 10.3987/COM-07-11262
One-Pot Synthesis of 2,3-Disubstituted Benzo[b]thiophene Derivatives from 2-Mercaptophenyl Ketones

Kazuhiro Kobayashi,* Daizo Nakamura, Shuhei Fukamachi, and Hisatoshi Konishi

*Department of Materials Science, Faculty of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan

Abstract

2-Mercaptophenyl ketones have been found to react with activated alkyl bromides (BrCH2EWG’s), such as bromoacetates, bromoacetonitrile, and bromomethyl phenyl ketone, in the presence of two molar amounts of sodium hydride in THF at 0 °C to afford 2,3-disubstituted benzo[b]thiophenes in generally good to excellent yields.