Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 75, No. 3, 2008, pp.675-681
Published online, 14th December, 2007
DOI: 10.3987/COM-07-11255
A Simple Synthesis of α-Nitro-δ-keto Nitrile

Nagatoshi Nishiwaki,* Tomoko Nogami, and Masahiro Ariga*

*Department of Chemistry, Osaka Kyoiku University, Asahigaoka 4-698-1, Kashiwara, Osaka 582-8582, Japan


α-Nitro-δ-keto nitrile was effectively synthesized in one-pot from pyridinium salt of nitroisoxazolone by ring opening reaction followed by condensation with two molecules of acetone via pyrrolidinium salt of 2,4-di-aci-nitropentanedinitrile. The obtained α-nitro-δ-keto nitrile has a highly acidic hydrogen in addition to multi-functionality. These structural features are considered to be useful for the syntheses of polyfunctionalized compounds.