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Paper | Regular issue | Vol 75, No. 3, 2008, pp.611-618
Published online, 11th December, 2007
DOI: 10.3987/COM-07-11246
Synthesis and Bioactivity of Novel Bisphosphonate Derivatives

B. Hari Babu, G. Syam Prasad, M. F. Stephen Babu, Pallamreddy Haranath, S. Hemadri Reddy, and C. Naga Raju*

*Department of Chemistry, Sri Venkateswara University, Tirupati-517502, India

Abstract

Synthesis of novel bis-(2,10-dimethyl-4,8-di-t-butyl-12H-6-oxido-dibenzo[d,g] [1,3,2] dioxaphosphocin -6-yl) 2/3/4-substituted phenyl / heteroaryl-methanes were accomplished by Pudovic reaction. Addition of an equimolar quantities of 2,2’-methylene-bis (6-tert-butyl-4-methyl phenol) 1 and EtOH to PCl3 afforded cyclic condensation product. This on reaction with respective aldehydes followed by treatment with phosphorus (III) monochloride of 1, corresponding bisphosphonate intermediates were formed which on subsequent stirring at reflux temperature rearranged from P(III) to P(V) state.