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Paper | Regular issue | Vol 75, No. 3, 2008, pp.583-597
Published online, 7th December, 2007
DOI: 10.3987/COM-07-11240
Chlorotrimethylsilane Mediated Synthesis of 5-(2-Hydroxybenzoyl)pyrimidines from 3-Formylchromones

Sergey V. Ryabukhin,* Andrey S. Plaskon, Dmitriy M. Volochnyuk, Sergey E. Pipko, and Andrey A. Tolmachev

*Enamine Ltd. 23 A. Matrosova st., 01103 Kyiv, Ukraine


The recyclization of 3-formylchromones with a variety of 1,3-NCN-binucleophiles promoted by chlorotrimethylsilane was investigated. A simple and flexible general procedure for the synthesis of series of 5-(2-hydroxybenzoyl)pyrimidines and their heterofused analogues was proposed. A set of pyrimidines was obtained in high preparative yields.