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Note | Regular issue | Vol 75, No. 3, 2008, pp.655-660
Published online, 16th November, 2007
DOI: 10.3987/COM-07-11237
Facile One-Pot Reaction for the Regioselective Syntheses of 2H-[1,2,4]Thiadiazolo[2,3-a]pyrimidine Derivatives

Guohua Liu,* Mei Yao, Yunning Xue, Haibin Fang, and Xiqowei Cao*

*Department of Chemistry, College of Life and Environmental Science, Shanghai Normal University, Shanghai 200234, P. R. China


A convenient and rapid method for the preparation of 2H-1,2,4-thiadiazole[2,3-a]pyrimidine derivatives 3a-3e was developed. The investigations of their regioselective syntheses through a comparison of the different substituted groups on the pyrimidine ring using a semi-empirical MO calculation and an X-Ray crystallographic analysis was also discussed.