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Paper | Regular issue | Vol 75, No. 3, 2008, pp.537-554
Published online, 16th November, 2007
DOI: 10.3987/COM-07-11231
A Facile Synthesis of 4-Aryl-5-alkoxycarbonyl-6-hydroxy-6-methyl-4,5,6,7-tetrahydro-3-hydroxy-2-(pyridin-2-yl)indazoles and Their NMR Characterizations

Shanmugasundaram Amirthaganesan, Gopalakrishnan Aridoss, Young Hwan Park, Jong Su Kim, Se Mo son, and Yeon Tae Jeong*

*Division of Mage and Information Engineering, Pukyong National University, Busan 608-739, Korea


A series of N-pyridinyl tetrahydroindazoles have been synthesized by a convenient and regioseletive method by taking cyclic β-ketoesters as scaffolds. An optimum reaction condition was achieved by monitoring the reaction in different reaction condition. One and two dimensional NMR spectroscopic investigations evidenced the formation and structure of the compounds. Besides, all the compounds have been achieved as a single isomer with pyridyl group at N(2). A suitable reaction mechanism was proposed.