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Communication | Regular issue | Vol 75, No. 2, 2008, pp.285-290
Published online, 30th October, 2007
DOI: 10.3987/COM-07-11211
Asymmetric Synthesis of Stellettamides A and C

Naoki Yamazaki,* Takeshi Suzuki, Yuta Yoshimura, Chihiro Kibayashi, and Sakae Aoyagi*

*School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


The first synthesis of the marine indolizidine alkaloids, (+)-stellettamide A and (-)-stellettamide C, has been achieved through a coupling reaction with the aminomethylindolizidine fragment and the chiral or achiral trienecarboxylic acid fragment, both of which could be derived from farnesol as a common precursor.