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Paper | Regular issue | Vol 71, No. 12, 2007, pp.2689-2697
Published online, 24th August, 2007
DOI: 10.3987/COM-07-11169
Microwave-Assisted Synthesis of N-2-Benzyl-3-(4-ethoxycarbonylphenyl)indazole Derivatives

Hua-Sin Chen, Li-Jiau Huang, Fung Fuh Wong,* Fang-Yu Lee, Che-Ming Teng, and Sheng-Chu Kuo*

*Graduate Institute of Pharmaceutical Chemistry, China Medical University, No. 91 Hsueh-Shih Rd. Taichung, Taiwan 40402, R.O.C.


The microwave-assisted synthesis for promoting N-2 substituted indazoles as the major products were successfully developed by treating 3-(4-ethoxycarbonylphenyl)indazoles with various substituted benzyl chloride (benzyl, o-chlorobenzyl, m-chlorobenzyl, and p-chlorobenzyl chloride) in the presence of two equivalents of triethylamine. The result was better than two trandional methods including the directly substitution with benzyl chloride and Mitsunobu reaction with benzyl alcohol.