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Note | Regular issue | Vol 71, No. 10, 2007, pp.2249-2262
Published online, 6th July, 2007
DOI: 10.3987/COM-07-11110
Synthesis and Friedländer Reactions of 5-Amino-4-cyano-1,3-oxazoles

M. Carmo Carreiras,* Ana Eleutério, Catarina Dias, M. Alexandra Brito, Dora Brites, J. Marco-Contelles, and Elena Gómez-Sánchez

*Faculdade de Farmácia, Universidade de Lisboa, Av. das Forças Armadas, 1600-083 Lisboa, Portugal

Abstract

The synthesis of 2-substituted 5-amino-4-cyano-1,3-oxazoles (1-4, 6-11) and the Friedländer-type reaction of compounds 1, 3, 4 is described. Compounds 13-17 are tacrine (18) analogues provided by the Friedländer reaction. The anti-cholinesterase activity of compounds 13, 14, 16 and 17 has been investigated.