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Note | Regular issue | Vol 71, No. 9, 2007, pp.2055-2061
Published online, 12th June, 2007
DOI: 10.3987/COM-07-11102
Pecrassipines A and B, Seco-Bisbenzylisoquinoline Alkaloids from Phaeanthus crassipetalus

Khalijah Awang,* Saripah Salbiah Syed Abd. Azziz, A. Hamid A. Hadi, Hiroshi Morita, Yusuke Hirasawa, Toru Iizuka, Marc Litaudon, and Mat Ropi Mukhtar

*Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

Chemical investigation on the bark of Phaeanthus crassipetalus (Annonaceae) yielded two new seco-bisbenzylisoquinoline alkaloids, (+)-pecrassipine A (1) and (-)-pecrassipine B (2), together with seven known alkaloids. Their structures were elucidated by two-dimensional NMR techniques. Pecrassipines A and B exhibited a vasorelaxant activity on isolated rat aorta ring.