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■ New Kehokorins and Trichiols from the Myxomycete Trichia favoginea

Kousuke Watanabe, Takashi Ohtsuki, Yukinori Yamamoto, and Masami Ishibashi*

*Graduate School of Pharmaceutical Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

Abstract

Two new dibenzofurans, kehokorins D (1) and E (2), and two new sterols with a 2,6-dioxabicyclo[2.2.2]octan-3-one ring, trichiols C (3) and D (4), have been isolated from field-collected fruiting bodies of the myxomycete, Trichia favoginea, and their structures were elucidated by spectral analysis. Kehokorins D (1) and E (2) showed cell growth inhibition activity against HeLa cells with IC₅₀ values of 6.1 and 4.5 μg/mL, respectively.